Variant BA.5 Covid : France, symptômes, durée, contagion

Variant BA.5 Covid : France, symptômes, durée, contagion

BA.5, a subvariant of the Omicron variant, predominates in France but its circulation decreases in August. Among the clinical signs: fatigue, vomiting and sore throat. The duration of the signs can be up to 7 days. Symptoms, duration, contagion, treatments… All about the covid BA.5 variant

The initial virus of the Covid-19 disease, Sars-Cov-2, mutated several times to the variant omicron which began to arrive at the end of 2021 in France. Now ubiquitous, this variant has five sublineages of which the BA.5. It has been the majority in France for several weeks, reports Public Health France on your last point. the symptom the most common are fatigue, cough, fever, headache and sore throat. Vomiting, diarrhea, and night sweats they are equally informed. This BA5 variant is “highly communicable but not more serious” recalled the president of the Covid Scientific Council on July 11 on France Inter. People positive and vaccinated should be isolated 7 days or 5 days in case of a negative test on day 5 and in the absence of symptoms for 48 hours on day 5.

What is the BA.5 variant?

BA.5 is a sublineage of the Omicron variant of Covid-19. Identification began in January and February 2022 in South Africa according to ECDC; early April according to Public Health France. was issued in Portugal, giving rise to a new wave of Covid-19 in May that was especially virulent for those over 80 years of age. He is particularly watched because he has L452 mutations (such as BA.4) associated with the highest transmissibility of Delta.

What are the symptoms of the BA.5 variant?

According to Santé Publique France, the most frequent clinical signs in case of infection by the BA.4 and BA.5 variants are fatigue, cough, fever and headache. The rest, “the probability of present anosmia [perte d’odorat] and ageusia [perte du goût]but also nausea, vomiting and diarrhea is higher for BA.4/BA.5″ boxes says the health agency. HASInstead of lasting an average of 4 days, they last rather 7 days or even 10 days so we pollute more time“, explained Dr. Damien Mascret on June 27. a new symptom is reported by Professor Luke O’Neill of Trinity College Dublin (Ireland): night sweats : “The disease is different because the virus has changed, night sweats are a new symptomthe immunologist told Irish Newstalk radio on July 7.

Age and symptoms of BA.4 and BA.5 cases compared to BA.1 cases as of June 15 © Public Health France

How long do the symptoms of the BA5 variant last?

the duration of clinical signs is on average 7 days for the cases of BA.4 and BA.5 versus 4 days for other Omicron cases.

What is the rate for the BA.5 variant in France?

Within the Omicron variant, the gradual replacement of the BA.2 sublineage by BA.5 continues and the latter has become majority in metropolitan France since June 13, 2022. BA.5 represented 92% of the screens analyzed by Public Health France in the July 11 Flash survey (compared to 3.6% for BA.2 which it replaced). As for BA.4, it was detected in 6.2% of the sequences.

Omicron variant sublineages during the July 2022 Flash polls
Omicron Variant Sublineages During Flash Surveys Jul 18, 2022 © Public Health France

Is the BA.5 variant more contagious?

The BA5 is more contagious than BA2. Taking into account the fact that it is more contagious, escapes post-vaccination immunity a little better so we’ll probably still see this resurgence of new cases in the coming weeks“, explained Yves Buisson, president of the Covid cell of the Academy of Medicine in Europe on June 7. The symptoms last longer (7-10 days)”so we pollute more time“explained Dr. Damián Mascret June 27th. The Omicron BA.4 and BA.5 sublines replaced the BA.2 and resulted in a new epidemic wave in South Africa (fifth wave). Same for the BA.5 exclusively in Portugal (with greater epidemiological impact in those over 80 years of age).

In South Africa: the BA.4 growth rate is +8% per day compared to BA2; +12% for BA.5.

In Portugal :BA.5 was associated with a resumption of the epidemic, but the peak of this wave that began in late April now appears to have passed. If this is confirmed, the amplitude of the wave will have been much smaller than the previous one.reported French Public Health on June 15.

Is the BA.5 variant more dangerous?

Data accumulated in several countries did not observe an increase in severity associated with BA.4 and BA.5. A first study from South Africa comparing the risk of serious events between the Omicron BA.1 wave and the BA.4/BA.5 wave showed similar risks of hospitalization or death between waves BA.1 and BA.4/BA.5, reports Public Health France on July 6. These two Omicron waves were associated with lower risks compared to previous waves. The risk of hospitalization/death was less in previously infected cases (70% less) or vaccinated 3 doses (83% lower) compared to uninfected/vaccinated cases. “Median length of hospitalization (for BA4 or BA5 cases, editor’s note) is 5 days“Indicated Public Health of France on June 15.

Are vaccines against the BA.5 variant effective?

Only preliminary UK data found no significant difference in vaccine efficacy for BA.4 and BA.5 compared to BA.2, reported Santé Publique France in the July 6 Variant Risk Analysis. Analysis of the BA.4/BA.5 wave in South Africa found a hospitalization rate similar to that of the BA.1 wave. “These data support a Vaccine efficacy and comparable severity for BA.4 and BA.5 compared to previous Omicron sublines” estimates Public Health France.

What treatments are effective if you are contaminated with the BA.5 variant?

the paxlovid it remains the first-line curative treatment regardless of SARS-CoV2 variant or subvariant. “Its activity is unchanged against BA.4 and BA.5 compared to subvariants BA.1 and BA.2” confirms the General Directorate of Health on July 11. This antiviral is administered orally. It can be prescribed by any doctor and is available in health facilities and community pharmacies from February 2, 2022. In case of contraindications to Paxlovid (in particular related to drug interactions), the treatment evusheld (tixagevimab 150 mg/cilgavimab 150 mg) is available. It is administered in health centers intramuscularly.

What are the differences between the BA.5 variant and the BA.2 variant?

BA.4, BA.5 spread better than BA.2. East (BA5, editor’s note) it escapes the vaccine a little better. And it shows the evolutionary capacity of the virus that is able to evade vaccines, while increasing its transmission. But we also know that symptoms are not more severe“, said epidemiologist Anne-Claude Crémieux on June 22 on FranceInfo. “These two sub-lineages are quite similar to BA.2 but your Spike protein also has the mutations L452R/F486V and the reversion R493Q. BA.4 and BA.5 soon replaced BA.2 in South Africa. BA.4 and BA.5reported French Public Health on May 18. The mutation L452R, which was also found in the Delta variant, continues to increase in positive Covid tests in France. L’Middle Ages of the cases investigated in France is 47 years, higher than that of cases of infection BA.1 (35 years).

Sources:

– Risk analysis on emerging variants of SARS-CoV-2 carried out jointly by Public Health France and the CNR for viruses of respiratory infections, July 6, 2022.

– Risk analysis on emerging variants of SARS-CoV-2 carried out jointly by Public Health France and the CNR for viruses of respiratory infections, June 15, 2022.

– Epidemiological update: SARS-CoV-2 Omicron sublines BA.4 and BA.5, ECDC, May 13, 2022

– Epidemiological Bulletin, Public Health France


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