Malaria: Vaccine results raise hopes for mass rollout

Malaria: Vaccine results raise hopes for mass rollout

A booster dose of a new malaria vaccine maintains a high level of protection against the disease, an international research team said Thursday in the journal Lancet Infectious Diseases, raising hopes that this inexpensive vaccine could be produced on a large scale within a few years. This vaccine, developed by scientists at the University of Oxford, could represent a turning point in the fight against the disease, the researchers said. Malaria, a mosquito-borne parasitic disease, killed 627,000 people, mostly African children, in 2020 alone.

Last year, another vaccine, produced by the British pharmaceutical giant GSK, became the first malaria vaccine recommended for widespread use by the World Health Organization (WHO). Since then, it has been administered to more than a million children in Africa. But research has shown that the efficacy of GSK’s vaccine is around 60% and drops dramatically over time, even with a booster dose. Oxford’s R21/Matrix-M vaccine was found to be 77% effective in preventing malaria, according to a study published last year. This is the first time that a vaccine has exceeded the efficacy target set by the WHO by 75%.

Also read: Article reserved for our subscribers “Every minute, a child under 5 years of age dies of malaria in the world”

For the study, 450 children aged 5 to 17 months in Burkina Faso, where malaria accounts for around 22% of all deaths, received three doses in 2019. They were divided into three groups: two received different doses of the adjuvant Matrix-M, a vaccine ingredient patented by Novavax and also used in the US biotech company’s Covid-19 vaccine; the third control group received a rabies vaccine.

Ahead of the 2020 rainy season (when malaria cases rise), 409 children returned for a booster shot. For the group that received the highest dose of adjuvant, the effectiveness of the vaccine increased to 80%, according to the results of a phase 2 trial published Thursday. For the lowest dose, the efficacy was 70%. Importantly, one month after receiving the booster, antimalarial antibodies returned to a level similar to that seen after the first doses received a year earlier, according to the study.

200 million doses per year

“It’s fantastic to see such high efficacy after just one booster dose”, welcomed one of the study’s authors, Halidou Tinto, from the Burkina Faso Health Research Institute (IRSS). Tinto, who was involved in the trial of both malaria vaccines, said GSK’s vaccine had optimal efficacy of around 60%. “Therefore, I can confirm that R21 [le vaccin d’Oxford] it is much more effectivehe said at a press conference.

“We could see a very substantial reduction in this horrible burden of malaria, a reduction in deaths and illnesses in the years to come, certainly by 2030.”said Adrian Hill, a vaccine specialist at Oxford and a co-author of the study. According to him, a 70% reduction in malaria deaths could be achieved within that time frame, in part thanks to the large number of vaccine doses that could be produced quickly.

Also read: Malaria: Niger gives “green light” to vaccination of children under 5

Oxford has partnered with the world’s largest vaccine manufacturer, the Serum Institute of India. The latter “Wishes and is able to manufacture 200 million doses a year from next year”said Mr. Hill. The 6 to 10 million doses that GSK can produce per year are not “It is not enough for 40 million children who need four doses in the first year”he said. And the Oxford vaccine would probably cost a few dollars per dose, less than half the $9 price of the GSK version, he added.

Results from a phase 3 trial involving 4,800 participants in four countries are expected later this year, which could lead to approval of the vaccine.

In order not to miss any African news, subscribe to the newsletter of the “World Africa” from this link. Every Saturday at 6am, find a week’s worth of news and discussions covered by the editorial staff of the “World Africa”.

The world with AFP

#Malaria #Vaccine #results #raise #hopes #mass #rollout

Leave a Reply

Your email address will not be published. Required fields are marked *